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Job ID :
59861BR
Location :
India - Bangalore
:
Job Description

Qualification

• Applicants should have a Masters with 5 + years experience or a PhD in the area of structural biology, biochemistry or biophysics integrated with cell biology, molecular biology, immunology or related fields. Experience in Structural biology is a must.

• GLP, GMP or any other certification in laboratory practices and EHS certification will be considered as a bonus

Responsibilities

  • Structure based design of antigens for antibody development – proteins, peptides, nucleotides etc.
  • Analysis of protein structures, peptide design and modifications
  • Solubility analysis, hydropathy plots, handling primary, secondary and tertiary protein structure.
  • Navigating through databases, handling various simulation softwares and analytics
  • Reviewing and evaluating various conjugation methodologies, carrier protein chemistries, haptens etc.
  • Involved in antigen production using various recombinant protein expression methodologies and bacterial, insect or mammalian cell culture systems
  • Antibody-antigen affinity analysis using SPR, Biacore etc.
  • Responsible for data integrity and accuracy.
  • Organizing data reviews and team meetings.
  • Presenting at national and international conferences.
  • Other functions such as writing technical protocols and filling out order forms.
  • Deliver high quality results according to project schedule in support of product commercialization during early feasibility, development and validation phases.

Skills

  • Well-versed in solubility analysis, primary, secondary and tertiary protein structure databases, softwares and analytics
  • Has extensive experience in crystallography and biophysical methods.
  • In depth knowledge of various conjugation methodologies, carrier protein chemistries, haptens etc.
  • Well-versed with recombinant protein expression methodologies using bacterial, insect and mammalian cell culture systems
  • Has extensive recombinant protein purification experience.
  • Experience in antibody-antigen affinity analysis using Biacore, Octet etc.
  • Well-versed in Structure-function analysis using site-directed mutagenesis or other strategies
  • GLP experience, documentation and automation
  • Publications in peer-reviewed journals would be a bonus. Good understanding of research projects using standard techniques and protocols.
  • Should be a good team player, ready to learn new techniques and innovative thinker.
  • Industry experience, bioinformatics and grant writing skills will be considered as a bonus.
  • Excellent organizational skills with attention to detail.



Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.
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